Illustration from first edition of LIFE ON THE MISSISSIPPI

How solemn and beautiful is the thought that the earliest pioneer of civilization, the van-leader of civilization, is never the steamboat, never the railroad, never the newspaper, never the Sabbath-school, never the missionary -- but always whiskey! Such is the case. Look history over; you will see. The missionary comes after the whiskey -- I mean he arrives after the whiskey has arrived; next comes the poor immigrant, with ax and hoe and rifle; next, the trader; next, the miscellaneous rush; next, the gambler, the desperado, the highwayman, and all their kindred in sin of both sexes; and next, the smart chap who has bought up an old grant that covers all the land; this brings the lawyer tribe; the vigilance committee brings the undertaker. All these interests bring the newspaper; the newspaper starts up politics and a railroad; all hands turn to and build a church and a jail -- and behold! civilization is established forever in the land. But whiskey, you see, was the van-leader in this beneficent work. It always is. It was like a foreigner -- and excusable in a foreigner -- to be ignorant of this great truth, and wander off into astronomy to borrow a symbol. But if he had been conversant with the facts, he would have said: Westward the Jug of Empire takes its way.
- Life on the Mississippi